Correction for “ Neighbor of Brca 1 gene ( Nbr 1 ) functions as a negative regulator of postnatal osteoblastic bone formation and p 38 MAPK activity , ” by Caroline
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DEVELOPMENTAL BIOLOGY Correction for “Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity,” by Caroline A. Whitehouse, Sarah Waters, Katie Marchbank, Alan Horner, Neil W. A. McGowan, Jelena V. Jovanovic, Guilherme M. Xavier, Takeshi G. Kashima, Martyn T. Cobourne, Gareth O. Richards, Paul T. Sharpe, Tim M. Skerry, Agamemnon E. Grigoriadis, and Ellen Solomon, which appeared in issue 29, July 20, 2010, of Proc Natl Acad Sci USA (107:12913–12918; first published June 29, 2010; 10.1073/ pnas.0913058107). The authors note that Figure 4 appeared incorrectly. A well image was duplicated within panel C. The corrected figure and its legend appear below. This error does not affect the conclusions of the article.
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Correction for “ Neighbor of Brca 1 gene ( Nbr 1 ) functions as a negative regulator of postnatal osteoblastic bone formation and p 38 MAPK activity
DEVELOPMENTAL BIOLOGY Correction for “Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity,” by Caroline A. Whitehouse, Sarah Waters, Katie Marchbank, Alan Horner, Neil W. A. McGowan, Jelena V. Jovanovic, Guilherme M. Xavier, Takeshi G. Kashima, Martyn T. Cobourne, Gareth O. Richards, Paul T. Sharpe, Tim M. Skerry, Agamem...
متن کاملNeighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
The neighbor of Brca1 gene (Nbr1) functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a scaffold protein to regulate growth-factor receptor and downstream signaling pathways. We show that genetic truncation of murine Nbr1 leads to an age-dependent increase in bone mass and bone mineral density through increased osteoblast d...
متن کاملبررسی الگوی متیلاسیون و بیان ژن APC به دنبال تمایز سلولهای بنیادی مزانشیمی مشتق از مغز استخوان به رده استئوبلاستی
Background and Aim: Different regulation processes have an effect on osteoblastic differentiation of mesenchymal stem cells (MSCs), and among them Wnt signaling pathway is particularly desirable. In Wnt signaling pathway, Adenomatous Polyposis Coli (APC) bind to β-catenin and induce its degradation, thereby acting as a negative regulator of canonical Wnt pathway. In this study, gene expression ...
متن کاملThe effect of resistance training and date pollen extract on bone tissue density and osteoblast cell proliferation in young male rats
Extended Abstract 1.Introduction One of the tissues that is affected by physical activity is bone. Bone is one of the tissues that needs to receive mechanical load to have normal function as a key factor in strengthening bone mass (2). Evidence shows that the mechanical load resulting from physical activity activates a set of proteins involved in the process of osteoblast activation and inhib...
متن کاملبررسی اثر ایزوپرترنول (آگونیست بتا آدرنرژیک) بر تمایز سلولهای بنیادی مزانشیمی مغز استخوان انسان به استئوبلاست در شرایط آزمایشگاهی
Background and Objective: The importance of β-adrenergic signals in bone formation and resorption has been well investigated. However, little is known about the role of β -adrenergic signals in osteoblastic differentiation of mesenchymal stem cells (MSCs), which is critically important in bone physiology and pharmacology. In this study, RUNX2 and Osteocalcin gene expression were quantified in M...
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تاریخ انتشار 2013